Dypyridamole CAS NO.58-32-2

Dipyridamole persantine Appearance:yellow crystalline powder Standard:BP /EP Dipyridamole (Persantine), a phosphodiesterase inhibitor that b…

Dipyridamole persantine Appearance:yellow crystalline powder Standard:BP /EP Dipyridamole (Persantine), a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.